The final practice session gave the premier class a good glimpse into race conditions, as usual, and this time it came with over 50 degrees of track temperature. The tyre combination of choice was a perhaps predictable hard front-soft rear but there were a few rebels looking for better pace on other tyre options. Often the agitator himself, the only scandalous thing about Marc Marquez in FP4 was his pace, consistently a tenth or so ahead of his rivals. His fastest lap however, was only one thousandth of a second ahead of compatriot Maverick Vinales, who was briefly tempted by a soft front but showed great pace once switching to the hard.
Joan Mir continued his fine performance in Jerez with third place in FP4, a tenth and a half faster than Jack Miller, who played around with the medium rear tyre. The gaps between the top Ducati and the rest of the top 15 were minuscule, with Alex Rins fifth and Franco Morbidelli sixth. Andrea Dovizioso was a bit subdued in seventh position, narrowly ahead of Pol Espargaro and Takaaki Nakagami.
After blasting through the lap record earlier in the day, Fabio Quartararo completed the top ten half a second behind the leader but showing decent pace in his runs. Cal Crutchlow in 11th spot was also only half a second off the lead, with the top 20 riders covered by one second. The last of those men was Aleix Espargaro, whose struggles with the Aprilia machine continue.