The warm afternoon in Valencia unveiled some hard slick tyres from their blankets and some new names made their way to the top of the timesheets. In a rare sight this weekend, Fabio Quartararo led the way early on, with pretty solid pace, until Takaaki Nakagami put Honda on top for the final five minutes. The Japanese rider gave Honda a reason to smile after a tough start to the day, which put Pol Espargaro out of action for the day, the Spaniard undergoing further medical checks after his scary FP3 crash but having avoided serious injury. Quartararo would have been happy enough with second, only six hundredths off top spot and the same gap keeping him ahead of Alex Rins.
Pecco Bagnaia was first of the Ducatis in fourth place, with Franco Morbidelli placing both factory Yamahas in the top 5. Joan Mir in sixth was only two tenths off top spot, while Alex Marquez found some speed to climb into 7th position after a slower start to his weekend. Miguel Oliveira also climbed up the timesheets quite significantly to secure 8th, while Jorge Martin and Maverick Viñales rounded out the top 10. FP3 leader Aleix Espargaro started the session with a minor tumble at turn 2 and ended it down in 12th place, while Ducati duo Johann Zarco and Jack Miller completed the top 15 positions, half a second off top spot.